Chelating Amphiphilic Polymers Field of the Invention
ثبت نشده
چکیده
Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydropho bic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures Such as micelles and poly mersomes. With suitable metals present in the form of coor dination complexes with 5 the chelating moieties, the chelat ing amphiphilic polymers of the invention are Suitable for use in various imaging techniques requiring metal labeling, Such as MRI (T1/T2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.
منابع مشابه
Benchmarking a Self-Consistent Field Theory for Small Amphiphilic Molecules
A minimalist self-consistent field theory for small amphiphilic molecules is presented. The equations for this model are less involved than those for block copolymers and are easily implemented computationally. A new convergence technique based on a variant of Anderson mixing is also presented which allows the equations to be solved more rapidly than block copolymer self-consistent field theory...
متن کاملModeling morphological instabilities in lipid membranes with anchored amphiphilic polymers
Anchoring molecules, like amphiphilic polymers, are able to dynamically regulate membrane morphology. Such molecules insert their hydrophobic groups into the bilayer, generating a local membrane curvature. In order to minimize the elastic energy penalty, a dynamic shape instability may occur, as in the case of the curvature-driven pearling instability or the polymer-induced tubulation of lipid ...
متن کاملRAPID COMMUNICATION Phosphonic Acid-Based Amphiphilic Diblock Copolymers Derived from ROMP
Forming nanostructures with controlled size and shape is one of the most challenging tasks in material science. Amphiphilic block copolymers are of special interest because of their ability to self-assemble on the nanoscale. The formation of micelles has potential applications such as in drug delivery, biosensors, and gene therapy. Ring-opening metathesis polymerization (ROMP) is a versatile te...
متن کاملPolymer based Nano-Assemblies: Very Efficient Carrier in the Field of Cancer Chemotherapy
Self-assembly of amphiphilic polymer opens a new avenue in the biomedical field; particularly, amphiphilic polymer vesicles have generally shown promising potential in drug delivery applications. The advantage of nanoparticle for drug delivery is because of the direct injection of these kind molecules to the body which will circulate in the body without any coagulation or blocking. The amphiphi...
متن کاملIron-Induced Fibrin in Cardiovascular Disease
Accumulating evidence within the last two decades indicates the association between cardiovascular disease (CVD) and chronic inflammatory state. Under normal conditions fibrin clots are gradually degraded by the fibrinolytic enzyme system, so no permanent insoluble deposits remain in the circulation. However, fibrinolytic therapy in coronary and cerebral thrombosis is ineffective unless it is i...
متن کامل